Posted February 22, 2010
Revised February 28, 2010
Copyright © by YSU Center for Applied Chemical Biology

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Dr. Chet Cooper
Director, Center for Applied Chemical Biology
Professor, Department of Biological Sciences
  • Ph.D., 1989, University of Texas at Austin
  • M.A., 1983, University of Texas at Austin
  • B.S., 1979, University of Pittsburgh at Johnstown
Telephone/Voice: 330.941.1361
Facsimile: 330.941.1483


Research Interests: 

My primary research interests focus on the molecular mechanisms of fungal morphogenesis and their association with pathogenicity.  In particular, my research seeks to understand the relationship of gene and protein expression patterns to virulence. The two model organisms used in these investigations are the dimorphic pathogens, Penicillium marneffei and Wangiella (Exophiala) dermatitidis.

Representative Publications:
  • COOPER CR Jr, Vanittanakom N.  Insights into the pathogenicity of Penicillium marneffeiFuture Microbiology 3: 43-55, 2008. [PubMed Link[PDF]
  • Liu H, Abramczyk D, COOPER CR Jr, Zheng L, Park C, Szaniszlo PJ. Molecular cloning and characterization of WdTUP1, a gene that encodes a potential transcriptional repressor important for yeast-hyphal transitions in Wangiella (Exophiala) dermatitidis. Fungal Genetics and Biology 45: 646-656, 2008.  [PubMed Link[OhioLink]
  • Chandler JM, Treece ER, Trenary HR, Brenneman JL, Flickner TJ, Frommelt JL, Oo ZM, Patterson MM, Rundle WT, Valle OV, Kim YD, Walker GR, COOPER CR Jr.  Protein profiling of the dimorphic, pathogenic fungus, Penicillium marneffei.  Proteome Science  6: 17, 2008.  [PubMed Link]  [Full Text/PDF]
  • Thirach S, COOPER CR Jr, Vanittanakom N.  Molecular analysis of the Penicillium marneffei glyceraldehyde-3-phosphate dehydrogenase gene (gpdA) and differential expression of gpdA and isocitrate lyase (acuD) upon internalization by murine macrophages.  Journal of  Medical Microbiology 57: 1322-1328, 2008.  [PubMed Link[Full Text/PDF]
  • Gifford TD, COOPER CR Jr. Karyotype determination and gene mapping in two clinical isolates of Penicillium marneffei.  Medical  Mycology 47:  286-295, 2009.  [PubMed Link] 
  • Vanittanakom N, Pongpom M, Praparattanapan J, COOPER CR Jr, Sirisanthana T.  Isolation and expression of the heat shock protein 30 gene from Penicillium marneffei.  Medical  Mycology 47: 521-526, 2009.  [PubMed Link]
  • Kummasook A, COOPER CR Jr, Vanittanakom N.  An improved Agrobacterium-mediated transformation system for the functional genetic analysis of Penicillium marneffei.  Medical Mycology [submitted for publication]
CACB Principle Investigators
[links to research project descriptions and contact information for each PI]
  >  Dr. David Asch
  >  Dr. Ganesaratnam Balendiran
  >  Dr. Jon Caguiat
  >  Dr. Chet Cooper
  >  Dr. Diana Fagan
  >  Dr. Jozsi Jalics
  >  Dr. Xiangjia Min
  >  Dr. Peter Norris
  >  Dr. Yogen Panta
  >  Dr. Doug Price
  >  Dr. Nina Stourman
  >  Dr. Gary Walker
  >  Mr. Rob Wardle
  >  Dr. George Yates

Other CACB Personnel
  >  Staff    
 Graduate Students
  >  Undergraduate Students
  >  Alumni


The CACB in Detail

   > Center Concept
> Scope of Activities
> Technological Capabilities
Sponsored Research Projects
> Faculty Research Groups
> Collaborators

Mycelial (left) and yeast (right) phases of Penicillium marneffei.

mold pm yeast
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